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Participants with mild cognitive impairment (MCI) as well as participants without memory concerns (normal controls) will be recruited for this study.
Criteria for either group:
For participants with mild cognitive impairment (MCI): impairment thought to be due to Alzheimer’s disease or a related degenerative dementia.
Further exclusions may apply.
White matter hyperintensities (WMHs) are bright patches that can only be see when pictures of the brain are taken through an MRI scan. WMHs are usually found in people with Alzheimer’s disease and related disorders.
UW researchers are investigating why white matter hyperintensities occur by analyzing blood biomarkers, cerebrospinal fluid, cognitive testing, and magnetic resonance imaging (MRI).
UW researchers are using innovative non-invasive MRI techniques to better understand white patches found in brain imaging that are related to poor blood supply to the brain and cognitive deficits in people with Alzheimer's disease. This study will test the link between MRI markers, cognitive performance, and markers in the cerebrospinal fluid (CSF), the fluid that surrounds the brain. Knowledge gained from this study will allow scientists to continue research aimed at alleviating cognitive decline and improving health.
Participants with mild cognitive impairment (MCI) will be recruited for this study.
The study takes place at two different institutions, the Veterans Affairs Hospital (VA) and the University of Washington Medical Center (UWMC). Two visits will take place at the VA and one at UWMC, 3 visits in total. The visits will be scheduled around your availability.
Visit 1: Veterans Affairs Hospital Seattle
Visit 2: Veterans Affairs Hospital Seattle
Visit 3: University of Washington Medical Center
Compensation is available.